How Do I Administer My Progesterone Injection?

The progesterone injection is different than the subcutaneous injections taken during an  IVF cycle. Your clinic will review specific instructions on how to administer it. Progesterone is an intramuscular (IM) injection and is applied deep into the muscle. The location site is the upper outer quadrant of the buttocks. It's important to be consistent and give yourself the injection around the same time each day (within 1 hour). 

Here are five tips to help your injection go smoothly:

  • Warm the sealed vial under tap water before use. Progesterone is mixed in either sesame or olive oil which is viscous (thick) and can be hard to inject. Warming the vial can help the process.
  • The vials are for multi-use. Be sure to clean the top of the vial with an alcohol prep with each use to avoid contamination. Use a new vial of progesterone in the event it has become contaminated.
  • When administering intramuscular injections, be sure to wash your hands and use a good sterile technique.
  • Applying a warm, moist compress to your body after administering the injection will help disperse the medication.


Contact your clinic if the site where you give yourself the injection becomes warm, red, itchy, inflamed or if you should develop a generalized rash on your arms, face or chest.