When Do I Take the Lupron Trigger?

If your doctor suspects that you will be at risk for Ovarian Hyperstimulation Syndrome (OHSS), he/she may plan your IVF protocol so that you can be a candidate for a Lupron trigger if needed. This type of trigger injection can only be used if you do not take Lupron (Leuprolide or Microdose) during your IVF cycle. You will still be instructed of a specific time at night to take this trigger injection, and your egg retrieval will still fall two days later in the morning. Your doctor’s office might ask you to come in for a Luteinizing hormone (LH) blood test to ensure the injection was effective. 

The reason a Lupron trigger will be beneficial for a patient who is at risk for OHSS is that it provides LH instead of HCG to prepare the follicles/eggs for the egg retrieval procedure. Because of the hormonal difference and the fact that LH does not stay in the body for a long period, you will be on estrogen supplementation after the egg retrieval. You will also be taking progesterone supplementation just as you would with an HCG trigger injection.